European Union recommendations on in vitro studies of interest for chemical testing

http://ihcp.jrc.ec.europa.eu/our_labs/eurl-ecvam/eurl-ecvam-recommendations

Predictive toxicology studies of relevance to in vitro studies

http://www.epa.gov/ncct/dsstox/

Industry notices and guidance documents of FDA by topic and by industry

http://www.fda.gov/ForIndustry/IndustryNoticesandGuidanceDocuments/default.htm

Virtual liver project

http://www.epa.gov/ncct/virtual_liver/

Independent assessment and validation of drug safety testing methods

http://c-path.org/programs/pstc/#

The following articles highlight the value of organotypic slice culture model:

• 3D Hepatic in vitro models as tools for toxicity studies. Current Tissue Engineering 2:78-89 (2013)
• Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction. Drug Metabolism and Disposition 34: 591-599 (2006)
• Organotypic cultures represent tumor microenvironment for drug testing. Drug Discovery Today: Disease Models 3(2):143-149 (2006)
• Toxicity testing: creating a revolution based on new technologies. Trends in Biotechnology 23 (6): 299-307 (2005)

Publications of interest on organ slice cultures:

• Fisher RL and Vickers AEM. Preparation and culture of precision-cut organ slices from human and animal. Xenobiotica, 43:8-14 (2013).
• Vickers AEM and Fisher RL. Evaluation of drug-induced injury and human response in precision-cut tissue slices. Xenobiotica, 43:29-40 (2013).
• Vickers AEM, Fisher R, Olinga P and Dial S. Repair pathways evident in human liver organ slices. Toxicology in Vitro, 25:1485-1492 (2011).
• Vickers AEM, Bentley P and Fisher RL. Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices. Toxicology in Vitro, 20:1173-1182 (2006).
• Nave R, Fisher R and Zech K. In vitro metabolism of ciclesonide in human lung and liver precision-cut tissue slices. Biopharmaceutics and Drug Disposition, 27:197-207 (2006).
• Vickers AEM and Fisher RL. Precision-cut organ slices to investigate target organ injury. Expert Opinion on Drug Metabolism and Toxicology, 1:687-699 (2005).
• Vickers AEM, Saulinier M, Cruz E, Merema MT, Rose K, Bentley P and Olinga P. Organ slice viability extended for pathway characterization: An in vitro model to investigate fibrosis. Toxicological Sciences, 82:534-544 (2004).
• Vickers AEM, Rose K, Fisher R, Saulnier M, Sahota P and Bentley P. Kidney slices of human and rat to characterize cisplatin-induced injury on cellular pathways and morphology. Toxicologic Pathology, 32:577-590 (2004).
• Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M, Bowden GT, Henderson CJ, Wolf CR, Clark AJ, Brendel K, Fisher RL and Gandolfi AJ. Precision-cut tissue slices from transgenic mice as an in vitro toxicology system. Toxicology in Vitro, 17:201-205 (2003).
• Fisher RL, Hasal SJ, Lipscomb JC, Gandolfi AJ and Brendel K. Cold- and cryopreservation of monkey liver slices. Toxicology Mechanisms and Methods, 12:1-15 (2002).
• Fisher RL, Ulreich JB, Nakazato PZ and Brendel K. Histological and biochemical evaluation of precision-cut liver slices. Toxicology Methods, 11:59-79 (2001).